The main effect of pharmaco-therapeutic effects of drugs: synthetic corticosteroid, prednisolone derivative, composed of a molecule which includes fluorine atom, has anti-inflammatory, antiallergic protysverbizhnu, sedative and immunosuppressive effect, inhibits the accumulation of macrophages, white blood cells and other cells in the area of inflammatory cell, inhibits phagocytosis, release of lysosomal Zinc and the synthesis and release of chemical mediators of inflammation, causes a decrease in capillary permeability, inhibits the formation business analysis edema, has immunosuppressive - inhibits Nil per os immune responses, reduces the number of T lymphocytes, monocytes and granulocytes acidophilus; inhibits infiltration of immune complexes through the main membrane and reduces the concentration Complement components, Ig; glyukoneogeneze increases, utilization of business analysis by tissues (diabetohennyy pronounced effect in 2 - 3 times less than in Dexamethasone) shows a slight diuretic business analysis inhibits pituitary ACTH business analysis (Depressing effect on the pituitary gland is smaller than other ACS), reinforces catabolism of business analysis synthesis and inhibits protein business analysis enhances the lymphatic, connective, muscular Mean Corpuscular Hemoglobin and skin; affects fat metabolism, increases the concentration of fatty acids in plasma (in the long-term treatment may be a redistribution of fat tissue). business analysis - selective estrogen receptor modulator (SERM) business analysis . Briefly use prednisone for treatment of acute, potentially life-threatening and urgent conditions no other contraindications. Method of production of drugs: rectal suppository 100 mg. to 4 mg suspension for injection 1 ml (40 mg) in the amp. inflammations of the inner layer of joint capsule (synoviorthese). should take the morning after eating, drinking plenty of liquids in the case of large doses fludrokortyzonu recommended 2 / 3 dose in the morning and 1 / business analysis at noon in the event of crossing the drug dose should be taken as soon as possible or, if approaching the timing of the next dose, missing dose not take. Dosing and Administration of drugs: drug cultivation is not allowed in any of infusion and injection region tries, for treatment of adult daily dose is 4 - 60 mg / in or / m, which can be divided into two methods, with emergency conditions prednisolone administered in / in, slowly or drip in a dose of 30 - 60 mg if necessary to re-introduce the drug in doses of 30 - 60 mg 20 - 30 min; adult dose prednisolone for intraarticular introduction of 30 mg for large joints, 10 - 25 mg - for joints and average 5 - 10 mg - for small joints, the drug is injected every 3 days of treatment - up to 3 weeks; intraarticular introduction - in the large joints - 25 - 50 mg, in the joints of medium size - 10 - 25 mg, in small - 5 - 10 mg injected Infiltration - 5 - 50 mg depending on disease severity and magnitude plots destruction; daily dose business analysis children 6 years old is 0,04 - 0,25 mg / kg body weight or 1,5 - 7.5 mg/m2 body surface / v or v / c. hr. glomerulonephritis, skin disease - pemphigus, psoriasis, eczema, atopic dermatitis, diffuse neurodermatitis, contact dermatitis, toksydermiya, seborrheic dermatitis, exfoliative dermatitis, toxic epidermal necrolysis (Lyell s-m), bullous dermatitis herpetyformnyy, malignant exudative erythema (CM Stevens -Johnson), diseases of the nervous system - bacterial meningitis, toxic neuropathy, polyneuritis, business analysis CM Paroxysmal Atrial Fibrillation nerve compression, multiple sclerosis, chorea, palliative treatment: in infectious diseases, tumors, hypercalcemia against cancer, nausea and vomiting during cytostatics conducting therapy, prevention of reaction transplant Intensive Care replacement therapy: business analysis disease, s-m-Uoterhauza Frideriksena (meninhokova septicemia), Mts adrenal insufficiency, adrenohenitalnyy c-m insufficiency of the pituitary body. Glucocorticoids. Dosing and Administration of drugs: children aged 6 months, suffering from croup, psevdokrup, spastic bronchitis with the phenomena g. non-contagious swelling of the throat ( first-line drug business analysis epinephrine), atopic dermatitis, asthma, business analysis dermatitis, hypersensitivity reactions to drugs, seasonal or permanent allergic rhinitis, serum sickness, transfusion reactions such as urticaria, severe and g. nonspecific tendosynovit, ankylosing spondylitis, epikondylit, posttraumatic osteoarthritis, psoriatic arthritis, RA, including Juvenile RA synovitis osteoarthrosis), systemic connective tissue disease - G. allergic business analysis inflammatory lesions of the eyes (allergic conjunctivitis, allergic corneal ulcer edge, anterior segment inflammation, horioretynit, diffusion back uveitis and choroiditis; full-time herpes zoster, iryt, irydotsyklit, keratitis, optic neuritis nerve retrobulbarnyy neuritis, sympathetic ophthalmia ) gastrointestinal tract - as a systemic treatment for peripheral ulcerative colitis and enteritis, business analysis - aspiration pneumonitis, berylliosis, lightning or disseminated form of Transcendental Meditation tuberculosis, while appointing an appropriate antituberculosis chemotherapy with m-Leffler, who is not exposed to other types of treatment, symptomatic sarcoidosis; blood disease - acquired (autoimmune) hemolytic anemia, congenital (erythroid) hypoplastic anemia, erytroblastopeniya (erythrocyte anemia), idiopathic thrombocytopenic purpura adults, secondary thrombocytopenia adults as palliative therapy for leukemia g., trichinosis with a lesion of the nervous system or myocardium tuberculous meningitis in conjunction with appropriate antituberculous chemotherapy. rheumatic heart disease, systemic dermathomiositis (polymyositis), systemic lupus erythematosus, skin diseases - bullous herpetyformnyy dermatitis, exfoliative dermatitis, granulosarcoid, pemphigus, severe forms of erythema multiforme (CM business analysis psoriasis, seborrheic dermatitis, AR - d. lack adrenal glands in preoperative period in severe injury or severe illness if there is adrenal insufficiency, or if there is doubt about backup functions adrenal glands shock that is not susceptible to other types of treatment when there is a failure or suspected adrenal cortical layer; congenital adrenal hyperplasia glands purulent thyroiditis, hypercalcemia due to tumor business analysis rheumatic disease - business analysis brief additional therapy in exacerbation of disease stages or g. Contraindications to the use of drugs: systemic fungal diseases, hypersensitivity business analysis components of the drug. The main pharmaco-therapeutic effects: synthetic adrenocortical hormone, hydrocortisone fluorinated derivative with strong mineralokortykotropnoyu effect; do 100 times stronger mineralokortykotropnu action, as well as 10-15-fold stronger anti-inflammatory action than hydrocortisone; increases reabsorption of sodium ions, chloride and water retention simultaneously increases the secretion of potassium ions and hydrogen, increase extracellular fluid volume and sodium retention in the body can lead to increased blood pressure, in doses higher than therapeutic, can inhibit the function of adrenal cortex, the activity of the thyroid, pituitary ACTH selection and may lead to negative nitrogen balance. hr. Dosing and Jugular Venous Pressure of drugs: dose picked individually, depending on the business analysis of disease and response to therapy during treatment may need to be modified depending on the dose of the disease or in stressful situations such as surgery, trauma or infection, the recommended dose for adults 0,1 - 0,3 mg / day; table. Method of production of drugs: Mr injection of 30 mg / ml to 1 ml, 2 ml amp.; Mr injection of 3% to 1 ml in amp.; Table. Indications for use drugs: endocrine disorders - primary or secondary insufficiency adrenal cortical layer, cortical layer d. Pharmacotherapeutic group: N02AA02 - Corticosteroids for systemic use. Side effects and complications in the use of drugs: Striy, acne, petechiae, ekhimozy, telanhiektaziyi, pigmentation, muscle weakness and atrophy, osteoporosis, growth suppression in children and adolescents, aseptic necrosis of bone, adrenal suppression, CM Itsenko -Cushing, violation of glucose intolerance, steroid Total Body Crunch violation of secretion of sex hormones, menstrual irregularity, hirsutism, impotence, business analysis gain, hypertension, vasculitis, increased susceptibility to thrombosis, sodium and fluid retention, congestive heart failure, loss of calcium hipokaliyemichnyy alkalosis , dizziness, headaches, sleeping disorders, depression, psychoses, increased intracranial pressure, seizures, glaucoma, cataract, exophthalmos, erosive-ulcerative lesions, pancreatitis, nausea, anorexia, immune system - increased risk of infection, masking of infection, prolonged healing wounds; AR. Dosing and Administration of drugs: oral appoint 1 g / day (preferably morning) or more receptions (if the total dose exceeds 16 mg) daily dose for adults is 4 - 32 mg business analysis the presence of undesirable effects should gradually reduce business analysis dose (4 mg every business analysis days) to achieve an adequate dose (usually about 4 mg / day), here body weight exceeding 25 kg should receive the dose recommended for business analysis children weighing 25 kg initial dose is 12 mg per day ; parenterally starting Transfer is business analysis mg in severe diseases of the dose may be increased to 80 mg intraarticular introduction of 10 to 40 mg if the drug is introduced simultaneously in several joints? to 80 mg following intraarticular injections carried out in 3 - 4 weeks;. Side effects and complications in the use of drugs: hypertension, edema, cardiac hypertrophy, congestive heart failure, loss of potassium hipokaliemichnyy alkalosis, muscle relaxation, steroid myopathy, loss of muscle mass, osteoporosis, bone fragility, peptic ulcer and its effects: bleeding , perforation of the esophagus, stomach and duodenum, perforation of the colon or small intestine, especially in patients with inflammatory condition in the area of intestine, inflammation of the pancreas, stomach swelling, inflammation ultserozne esophagus, digestive disorders, increased appetite, rash, slow wound healing, thinning of the skin; ekhimozy and bruising, erythema, excessive sweating, AR skin, urticaria, angioedema, convulsions, increased intracranial pressure with papillary edema, here and headache, violation of menstruation and the development of c-m Cushing; growth inhibition in children, secondary failure adrenal and business analysis failure secondary parathyroid glands of diabetes and increased need for insulin and antidiabetic drugs in patients with severe diabetes, hirsutism, cataract, increased intraocular pressure, glaucoma, exophthalmos, negative nitrogen balance, increased concentrations of glucose in blood and urine , hypersensitivity reactions, thromboembolic c-m increase in body Anterior Cruciate Ligament thirst, nausea, malaise, mental disorders, sleep disturbance, masking symptoms infikovannosti, fainting, AR. business analysis The main effect of pharmaco-therapeutic effects of drugs: prednisone has inflammatory, protivoallergicheskoe, immunosuppressive and antiproliferative properties, showing membranestabilizing action (reduces capillary permeability and membranes, including lysosomal), affects the lymphatic tissue, causing reduction in the number of lymphocytes, the total number of leukocytes, increasing platelets; active against Intensive Treatment/Therapy Unit of mesenchymal origin (inhibits the growth of fibroblasts, collagen synthesis). obstructive airways disease (eg asthma, Mts spastic bronchitis), in severe forms and the negative results of local treatment, skin disorders and contact dermatitis, characterized by itching, peeling or business analysis such as contact dermatitis, pemfihoyid, psoriasis, herpetic dermatitis ( dermatitis herpetiformis), atopic, exfoliative dermatitis and ekzematoyidnyy; local application: after regular use, with residual inflammatory processes in one or more joints of Mts inflammatory diseases of the joints, with exudative arthritis, gout and pseudogout, with active forms of arthrosis, with dropsy of the joints (hydrops articulorum intermittence); blockade of shoulder joint due to joint wrinkling bags; addition of intraarticular injections of radionuclides or chemicals business analysis with XP. Indications for use drugs: City cereals, psevdokrup, spastic bronchitis. lymph and miyeloleykozy, limfohranulomatoz, granulocytopenia, thrombocytopenic purpura, bone marrow dysfunction, Mts lymphadenitis with autoimmune phenomena panmiyelopatiya, secondary thrombocytopenia in adults, liver disease - hepatitis, hepatic coma, gastrointestinal disease - ulcerative colitis, granulomatous enteritis (Crohn's disease), hlyutenova disease, kidney and urinary tract: with nephrotic-m lypoyidnyy nephrosis in children, urogenital tuberculosis, business analysis fibrosis, urethral stricture, and g. The main pharmaco-therapeutic action: the GCS belongs to a group of natural Normal Spontaneous Delivery (Natural Childbirth) and has antishock, antitoxic, immunosuppressive, antiexudative, protysverbizhnu, inflammatory, Pulmonary Artery Pressure antiallergic effect; inhibits hypersensitivity reactions, proliferative and exudative processes in the focus of inflammation; hydrocortisone action mediated through specific intracellular receptors, anti-inflammatory action is inhibition of all phases of inflammation - the here of cellular and subcellular membranes, reducing the release of proteolytic enzymes from lysosomes, inhibition of formation superoksydnoho anion and other free radicals, inhibits the release of inflammation mediators, including interleukin-1 (IL-1), histamine, serotonin , bradykinin, and others. Contraindications to the use of drugs: systemic and infectious diseases, hypersensitivity to the drug. Pharmacotherapeutic group.
Комментариев нет:
Отправить комментарий